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(See,,,,"Physiology,,,,of,,,,gastric,,,,acid,,,,secretion",,,,and,,,,"Overview,,,,and,,,,comparison,,,,of,,,,the,,,,proton,,,,pump,,,,inhibitors,,,,for,,,,the,,,,treatment,,,,of,,,,acid-related,,,,disorders".)ANTACIDSAntacids,,,,usually,,,,contain,,,,a,,,,combination,,,,of,,,,magnesium,,,,trisilicate,,,,,aluminum,,,,hydroxide,,,,,or,,,,calcium,,,,carbonate.,,,,v,,,,t,,,,e,,,,GlaxoSmithKline,,,,Subsidiaries,,,,GlaxoSmithKline,,,,Pakistan,,,,GlaxoSmithKline,,,,Pharmaceuticals,,,,Ltd,,,,Stiefel,,,,Laboratories,,,,ViiV,,,,Healthcare,,,,(85%),,,,Predecessors,,,,,acquisitions,,,,Allen,,,,&,,,,Hanburys,,,,Beecham,,,,Group,,,,Block,,,,Drug,,,,Burroughs,,,,Wellcome,,,,Glaxo,,,,Glaxo,,,,Wellcome,,,,Human,,,,Genome,,,,Sciences,,,,Recherche,,,,et,,,,Industrie,,,,Thrapeutiques,,,,Reliant,,,,Pharmaceuticals,,,,S.,,,,All,,rights,,reserved.,,The,,most,,important,,appear,,to,,be,,their,,ability,,to,,reinforce,,the,,mucus,,layer,,covering,,gastric,,and,,duodenal,,mucosa,,which,,is,,buffered,,by,,HCO,,3,,PowerPoint,,Presentation:,,MECHANISM,,OF,,ACTION,,Misoprostol,,acts,,upon,,gastric,,parietal,,cells,,,inhibiting,,the,,secretion,,of,,gastric,,acid,,via,,G-protein,,coupled,,receptor-mediated,,inhibition,,of,,adenylate,,cyclase,,,,,which,,leads,,to,,decreased,,intracellular,,cyclic,,AMP,,levels,,and,,decreased,,pump,,activity,,at,,the,,apical,,surface,,of,,the,,parietal,,cell,,SIDE,,EFFECTS,,Diarrhea.,,GlaxoSmithKline,,Other,,Drug,,Industry,,Document,,Archive,,GlaxoSmithKline,,Prize,,Side,,Effects,,Study,,329,,Category,,.,,Account,,,,Join,,,,Now,,,,Sign,,,,In,,,,Premium,,,,My,,,,Presentations,,,,Education,,,,Specials,,,,RSS,,,,Featured,,,,Featured,,,,Audio,,,,Featured,,,,Animated,,,,Latest,,,,Uploads,,,,Most,,,,Liked,,,,Most,,,,Viewed,,,,Featured,,,,Lessons,,,,Browse,,,,Podcast,,,,Featured,,,,Featured,,,,Audio,,,,Featured,,,,Animated,,,,Latest,,,,Uploads,,,,Most,,,,Liked,,,,Most,,,,Viewed,,,,Categories,,,,Facebook,,,,App,,,,Developers,,,,Get,,,,your,,,,Widget,,,,Channels,,,,Latest,,,,Members,,,,PowerPointTemplatesNEW,,,,Help,,,,&,,,,Info,,,,About,,,,Us,,,,Help,,,,API,,,,FAQ,,,,Contact,,,,Us,,,,Terms,,,,and,,,,Conditions,,,,Privacy,,,,Policy,,,,Blog,,,,Forum,,,,What's,,,,new?,,,,Careers,,,,Webinars,,,,Why,,,,authorSTREAM,,,,Feature,,,,Tour,,,,How,,,,it,,,,Works,,,,PowerPoint,,,,to,,,,Video,,,,&,,,,iPod,,,,PowerPoint,,,,on,,,,Blogs,,,,PowerPoint,,,,to,,,,Flash,,,,Share,,,,Presentations,,,,Online,,,,Present,,,,Live,,,,Presentations,,,,on,,,,iPad,,,,Presentation,,,,Analytics,,,,Branded,,,,Channels,,,,Video,,,,in,,,,PPT,,,,Greeting,,,,Cards,,,,Referral,,,,authorSTREAM,,,,Desktop,,,,Buzz,,,,on,,,,authorSTREAM,,,,Follow,,,,us,,,,on:,,,,,,,,Go,,,,to,,,,Application,,,,Have,,,,a,,,,question?,,,,Call,,,,us,,,,at,,,,US,,,,210-787-1860,,,,Open,,,,Monday,,,,to,,,,Friday,,,,,8,,,,AM,,,,to,,,,6,,,,PM,,,,EST,,,,,,,,2014,,,,authorSTREAM.,,,,A.;,,,,Heitlinger,,,,,L.,,,,(1994).,,Proton,,pump,,inhibitor,,and,,histamine,,2,,receptor,,antagonist,,use,,and,,vitamin,,B12,,deficiency.,,PPIs,,are,,also,,more,,effective,,in,,preventing,,NSAID-induced,,gastroduodenal,,toxicity,,and,,in,,healing,,gastroduodenal,,ulcers,,associated,,with,,NSAIDs,,when,,they,,cannot,,be,,discontinued.,,Sucralfate,,,,can,,,,also,,,,bind,,,,to,,,,phosphate,,,,and,,,,lead,,,,to,,,,hypophosphatemia,,,,[37].,,,,Another,,,PCAB,,,,revaprazan,,,,has,,,been,,,approved,,,in,,,Korea.,,,(See,,,,"NSAIDs,,,,(including,,,,aspirin):,,,,Primary,,,,prevention,,,,of,,,,gastroduodenal,,,,toxicity",,,,,section,,,,on,,,,'Misoprostol'.)POTASSIUM-COMPETITIVE,,,,ACID,,,,INHIBITORSPotassium-competitive,,,,acid,,,,inhibitors,,,,(PCABs),,,,work,,,,by,,,,competing,,,,for,,,,potassium,,,,on,,,,the,,,,luminal,,,,side,,,,of,,,,the,,,,parietal,,,,cell,,,,,and,,,,cause,,,,rapid,,,,and,,,,reversible,,,,inhibition,,,,of,,,,pumps,,,,and,,,,therefore,,,,acid,,,,secretion,,,,[55].,,,,McGraw-Hill.,,3:,,896903.,, 6704223018
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